What is vntyper-online?

vntyper-online offers online MUC1 VNTR genotyping using the VNtyper algorithm. The MUC1 read data is extracted locally in your browser from BAM files and only this subset is uploaded to the server for analysis.

How do I upload my data?

Upload BAM, BAI, or SAM files using the file input section. For BAM files, ensure each has a corresponding BAI file. SAM files from IGV can also be uploaded after navigating to the MUC1 region.

vntyper.org uses SSL/HTTPS with strong encryption (Mozilla Observatory A+, SSL Labs A+). Only a small fraction of the BAM file is uploaded, preserving privacy. Read data is immediately deleted after computation, and results are kept for 7 days before deletion.

What regions can I analyze?

Select the reference assembly used for your alignment. The region corresponding to the MUC1 locus will be automatically selected for analysis.

Online MUC1 VNTR Genotyping for ADTKD Diagnostics

Screen BAM files for MUC1 coding VNTR mutations using VNtyper 2.0. Fast, secure, browser-based analysis for autosomal dominant tubulointerstitial kidney disease (ADTKD-MUC1, MCKD).

Upload sequencing files:

Drag & drop BAM, BAI, or SAM files or click to select multiple files.

No files selected.

Select reference:

Your results will appear here after job submission.

Please cite: Saei H, et al. VNtyper enables accurate alignment-free genotyping of MUC1 coding VNTR using short-read sequencing data in autosomal dominant tubulointerstitielle nierenerkrankung. iScience. 2023 Jun 17;26(7):107171. doi: 10.1016/j.isci.2023.107171. PMID: 37456840; PMCID: PMC10338300.

Online MUC1 VNTR Genotyping for ADTKD Diagnostics

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